# M3 – Monologues, MRI, Miscellanea

## Why are T1 and T2 of water what they are?

posted on 2019-02-18 (by Olaf Dietrich)

Relaxation is one of the most basic and obvious effects in nuclear magnetic resonance (NMR) experiments. Relaxation describes how the nuclear magnetization returns to its equilibrium state after an excitation by a pulsed radio-frequency field. The transverse magnetization (precessing in the plane perpendicular to the external magnetic field B0 and yielding the measurable NMR signal) decays exponentially with a time constant called T2; the longitudinal magnetization (parallel to B0) recovers exponentially with a time constant called T1.

For pure (distilled) water, these relaxation times are in the order of 1 to 5 seconds as established by numerous experiments. However, the calculation of these relaxation time constants is known to be notoriously complicated and difficult (requiring detailed quantum mechanical analysis of the spin ensembles and the spin interactions); a typical result of such an analysis is shown in the figure below. Relaxation times as function of the viscosity expressed by the correlation time τc. Short correlation times (on the left) correspond to low viscosity; long correlation times (on the right) to high viscosity.

So I wondered if the NMR relaxation time constants T1 or T2 of pure water can be roughly estimated using only some simple assumptions and considerations such that the resulting quantities are at least in the correct order of magnitude.

The main reason for transverse and longitudinal relaxation is the magnetic dipole-dipole interaction between spins (other effects such as interaction with the thermal radiation field or electric interactions with the electrons can be neglected for the water protons). The dipole field of a magnetic moment m is

Bdipole(r) = (μ0)/(4π) (3r(m · r) – mr2)/(r5)

or, which is enough for our order-or-magnitude estimations,

Bdipole(r) ~ (μ0)/(4π) (|m|)/(r3),

where μ0 = 4π × 10–7 T2 m3 / J is the vacuum permeability.

The magnetic moment m of the proton can be easily expressed by the gyromagnetic ratio γ ≈ 267.5 × 106 rad / (sT), which is defined as the ratio between magnetic moment and angular momentum I, m = γI. Approximating the angular momentum I of the proton by I ~ ℏ ≈ 1.055 × 10–34 Js leads to |m| ~ γℏ ≈ 3 × 10–26 J / T and

Bdipole(r) ~ (μ0)/(4π) (γ)/(r3) ≈ 3 × 10–33(T m3)/(r3).

A first idea about T2 or transverse relaxation (introduced already 1946 in the seminal NMR paper by F. Bloch) is to consider spins (protons) in a rigid lattice, where the magnetic field of the nearest neighboring proton induces a phase shift at the spin of interest leading to signal dephasing. Using the shortest distance that is relevant for the nuclei in water molecules, namely the intramolecular proton-proton distance dpp ≈ 0.15 × 10–9 m, the additional, dephasing dipole field of a single neighboring proton is δB = Bdipole(dpp). This yields a dephasing angular frequency δω = γδB = γBdipole(dpp) (in addition to the Larmor frequency due to the external B0 field). Assuming that transverse relaxation requires an additional phase angle of the order of 1, the time constant T2 can be estimated to be of the order

(1)/(T2) ~ δω = γBdipole(dpp) ≈ (μ0)/(4π) (γ2)/(dpp3) ≈ (1)/(5 μs).

Well, this value for T2 ~ 5 μs is obviously way too small for water – by about 6 orders of magnitude! So we are not even close … but there is still something to learn from this: The very short T2 is in fact quite exactly what we find in solids (as e.g. in water ice with T2 ≈ 4 μs as measured by T. G. Nunes et al.), which shouldn’t be too surprising since we have assumed a rigid spin configuration above. Consequently, we’ve learned now that the constant random motion of water molecules in liquid water must play a very important role for the quantitative understanding of relaxation.

To obtain at least an order-of-magnitude estimation of the actual T2 relaxation time (and in fact also of T1) of liquid water, we have to include some additional information about the random motion of water molecules. A handy physical parameter to describe the effects of this random motion is the correlation time τc, which can be used to describe, e. g., a fluctuating magnetic field component B(t)B(t + τ)⟩ = ⟨B(t)2⟩ exp(–|τ| / τc), where ⟨ · ⟩ denotes the ensemble average over all spins and the result is assumed to be independent of the time t. So basically, after the correlation time τc the fluctuating field strength becomes statistically independent of its former values.

For the protons of water, this correlation time is extremely short, in the order of picoseconds: τc ≈ 5 × 10–12 s. This value is in fact about the diffusion time of a water molecule over a region with diameter dpp, which is dpp2 / (6D) ≈ 2 × 10–12 s for D ≈ 2 × 10–9m2 / s. It is important to note that there is almost no dephasing over the correlation time, i. e., τc δω ≈ 10–6 ≪ 1. This means that the static dephasing as assumed above cannot take place since the protons move too quickly and the static effects are averaged out. After about τc, the motion has completely changed the orientation of the vector distance r between the protons and, hence, also the magnetic dipole field direction and the magnitude of each field component.

To obtain an estimation of T2 using this correlation time, we now consider the phase angles ϕ(t) within our ensemble of spins after a time t – more exactly, the additional phase angles (as seen in a rotating frame of reference) due to the fluctuating random magnetic fields δB(t). These phase angles exhibit a random distribution with mean value ϕ(t)⟩ = 0, but the width of this distribution ϕ(t)2 increases proportional to the time ϕ(t)2⟩ = αt. Similarly as above, we estimate our relaxation time T2 to be the time required for this standard deviation to become of order 1; i. e., T2 ~ (1)/(α) = (t)/(ϕ(t)2).

What can we say about the value of α? The factor α must have the dimension of 1/time; it should increase with the local magnetic field strength δB = δω / γ and also with the correlation time τc (the longer the correlation time, the less effective becomes the averaging). So, the simplest approach to express α by the given quantities with the correct physical dimension is to set α = δω2τc. With this guess, we find

(1)/(T2) ~ δω2τc ≈ [(μ0)/(4π)(γ2)/(dpp3)]2 τc ≈ 0.25 s–1 ≈ (1)/(4 s)

in surprisingly good agreement with the experimental data.

To obtain a very similar result by an actual calculation, we can quantitatively determine the width of the distribution ϕ(t)2. The relation between the fluctuating magnetic field component δB(t) seen by an individual spin and the phase evolution of this spin is

ϕ(t) = t0ω(t’) dt’ = γt0δB(t’) dt

yielding

ϕ(t)2⟩ = γ2(t0 δB(t’) dt)2⟩ = γ2t0 dtt0 dt” ⟨δB(t’) δB(t”)⟩

or, by substituting τ = t” – t,

ϕ(t)2⟩ = γ2t0 dtt – tt δB(t’) δB(t’ + τ)⟩.

We can now use the correlation time relation from above for the fluctuating random magnetic field component δB(t), namely δB(t) δB(t + τ)⟩ = ⟨δB(t)2⟩ exp(–|τ| / τc) with the average squared field strength δB(t)2⟩ ~ Bdipole(dpp)2 ~ δω2 / γ2 to obtain

ϕ(t)2⟩ ~ δω2t0 dtt – tt  exp(–|τ| / τc).

To solve this double integral without long calculations (which are nevertheless straightforward), we need the fact that τc ≪ t and therefore almost always τc ≪ τ (the second integration variable), so the exponential function in the integral is almost always 0. The integrals over τ =  – t’…t – t’ (integration ranges shown as colored lines at the bottom) can be approximated by the integral over τ =  – ∞…∞ for almost all values of t’ (green examples); errors occur only for few values of t’ ≈ 0 or t’ ≈ t (red example).

Hence, the second (inner) integral can be approximated for almost all values of t as –∞exp(–|τ| / τc)  = 20exp(–τ / τc)  = 2τc. With this approximation, we find

ϕ(t)2⟩ ≈ δω2t0 dt’ 2τc = 2 δω2 τct

and, consequently,

(1)/(T2) ~ 2δω2τc ≈ 0.5 s–1 ≈ (1)/(2 s),

which is again an estimation that agrees well with the observed values.

A final short comment on T1: In non-viscous liquids such as water, T1 and T2 are approximately the same. While loss of phase coherence is required for T2 relaxation, energy transfer from individual spins to the liquid is causing T1 relaxation. This energy transfer occurs due to transverse fluctuating magnetic fields δBx,y(t) with spectral components agreeing with the Larmor frequency ω = γB0. Since these frequencies are much lower than the inverse correlation time, i. e., γB0 ≪ 1 / τc, they basically occur with the same probability as the dephasing T2 effects considered above. A more detailed analysis of T1 and T2 requires quantitative estimations of the spectral density functions J(ω) of the dynamic processes involved.

### Update (2019-02-29)

A concise introductory summary about some approaches and results of quantitative relaxation theory can be found in the text book “Principles of Nuclear Magnetic Resonance Microscopy” by Paul T. Callaghan, section 2.5.

Categorized: MRI, NMR, relaxation, physics
pdf version available
URL: <https://dtrx.de/od/mmm/mmm_20190218.html>

## What’s special about 1.256 431 208 626… in MRI?

posted on 2018-06-28 (by Olaf Dietrich)

Consider the following simple question in magnetic resonance imaging (MRI) or spectroscopy (MRS): Given a fixed total measurement time, Ttotal, (e. g., a typical breath-hold duration of 16 s or a maximum accepted sequence duration of 10 min) and the possibility to fit into this duration an acquisition with several repeated read-outs (that are to be averaged to increase the data quality), what is the optimum balance between the repetition time (TR or TR) and the number of averaged signals (also called simply the number of averages, N, or the number of excitations, NEX or Nex)? (For simplicity, let’s consider only pulse sequences with 90 ° excitations (e. g., spin-echo sequences), in which all available magnetization is flipped to the transverse plain in each repetition.)

### The solution (for 90° excitations) Dependence of the signal-to-noise ratio Ψ on the repetition time TR at fixed total measurement time with a maximum at TR / T1 = 1.256 431 208 626…

In general, a single MRI acquisition (without averaging) requires M repeated excitations separated by TR (e. g., M could be the number of phase-encoding steps for conventional spin-echo acquisitions or M = 1 for single-shot EPI or one-dimensional MR spectroscopy). Hence, the acquisition time without data averaging is Tacq = MTR, and, neglecting for now that the number of averages must be integer, this number of averages is N = Ttotal / Tacq = Ttotal / (MTR). In the following, the actual relevant time parameter is, thus, Tavail = Ttotal / M, the time available for each required excitation, and the number of averages is N = Tavail / TR. We can also express the repetition time by these parameters as:

TR = Tacq / M = Ttotal / (M N) = Tavail / N.

On the one hand, averaging data increases the obtainable signal-to-noise ratio (SNR or Ψ) proportional to the square root of the number of averages:

Ψ ∝ √(N) = √(Tavail / TR). Dependence of the SNR Ψ on the number N of averages (left) and the TR (right, at fixed total measurement time) due to averaging neglecting the influence of TR on T1 relaxation

On the other hand, increasing the number of averages (at fixed total measurement duration!) results in a shortened time for longitudinal relaxation: TR = Tavail / N and, thus, in less SNR:

Ψ ∝ 1 – exp(–TR / T1) = 1 – exp (Tavail)/(NT1). Dependence of the SNR Ψ on the number N of averages (left, at fixed total measurement time) and the TR (right) due to T1 relaxation neglecting the influence of signal averaging

The resulting total SNR is proportional to the product of both factors, i. e.,

Ψ ∝ √(Tavail / TR)(1 – exp(–TR / T1)): Resulting dependence of the SNR Ψ on TR at constant total measurement time (and thus, implicitly, on the number of averages) considering both averaging and relaxation effects

The SNR (as a function of TR at constant total measurement time) has, thus, a maximum in an intermediate range; for very short TR (and, consequently, many averages), the longitudinal magnetization cannot relax sufficiently, which reduces the available signal; for very long TR, the relaxation is approximately complete anyway, but the number of averages decreases.

To calculate the optimum TR (or N), TR and Tavail are best expressed in terms of T1 using τ = TR / T1 and T = Tavail / T1, which gives

Ψ ∝ √((T)/(τ))(1 – exp(–τ))

The maximum of this expression with respect to τ is obtained by setting its derivative to zero, i. e.

0 = ()/(τ) [√(T / τ)(1 – exp(–τ))] = (exp(–τ))/(2)√((T)/(τ3))(1 + 2τ – exp(τ))

which gives

1 + 2τ – exp(τ) = 0.

The solution of this equation is

τ =  – (1)/(2) – W–1(–1 / (2 √(e))) = 1.256 431 208 626…

where W–1 is the lower branch of the Lambert W-function (or product-log or Omega function, which gives the solution for W in z = Wexp(W), i. e., it is the inverse function of f(W) = Wexp(W)). Hence, the optimal choice for TR is (at least theoretically):

TR ≈ 1.256 T1.

Fortunately, the function to be maximized has a rather broad maximum, and one obtains values between 99 % and 100 % of the maximum SNR for TR between about 0.9937 T1 and 1.5773 T1 and values between 95 % and 100 % of the maximum SNR for TR between about 0.7293 T1 and 2.0882 T1 (values determined by numerical evaluation and illustrated in the first figure at the top).

So, practically, choosing TR to be T1 gives still a nearly optimal SNR; if a larger number of signal acquisitions is preferred, e. g., for statistical evaluation, then TR may even be shortened to 0.75 T1, and if – on the other hand – the base SNR of every single acquisition becomes very low (but is to be reconstructed before signal averaging) then TR may be chosen to be 2 T1 to increase the quality of each single (not averaged) data set.

The presented result is not new; in fact, it has been derived before (at least numerically) in several publications. An early example is, e. g., a publication by R. R. Ernst and R. E. Morgan (1973).

The presented analysis is valid only for simple 90° excitations; FLASH sequences or steady-state pulse sequences which refocus the transverse magnetization as well will exhibit a different behavior.

Of course, optimizing TR as described above is not an option if T1-weighted or T2-weighted images are to be acquired. In these cases, the optimal value of TR depends on the desired contrast and not on the total SNR.

(This is a shortened version of a slightly longer pdf document that contains some more details and discusses also a few special cases.)

Categorized: MRI, NMR, SNR, physics
pdf version available
URL: <https://dtrx.de/od/mmm/mmm_20180628.html>

## Looking for reference values of water diffusion?

posted on 2018-04-25 (by Olaf Dietrich)

This is a short advertisement for my web document “Diffusion Coefficients of Water”. If you have ever looked for reference values of the self-diffusion coefficient of water at different temperatures, then chances are that you might like to bookmark the link above. Screenshot from

(If you have never heard of molecular (self-)diffusion, then it’s probably not so relevant for you. As an ultra-short explanation: Self-diffusion is a term for the thermal motion of molecules. If we could look at the individual molecules of a liquid such as water (say, with a really big microscope), then we would see all molecules in constant random motion. This molecular motion is known as the cause of the Brownian motion, which has been observed already in 1827 by the botanist Robert Brown. The extent of this motion is directly related to the temperature of the liquid or – which is essentially the same – to the thermal kinetic energy of the molecules. This motion can be described by a physical quantity called the (self-)diffusion coefficient D, which has units of m2 / s. The meaning of a diffusion coefficient of, e. g., D = 2 × 10–3 mm2 / s is that after a time t = 1 s the space “visited” by an average diffusing molecule (in a certain statistical sense) has a size s (i. e., a radius) of s = √( 6Dt) = √( 12 × 10–3 mm2) ≈ 0.1 mm.)

Why is it good to know the exact relationship between the temperature and the diffusion coefficient of water? Typical applications are:

• Using these data, we can determine temperatures by measuring diffusion coefficients of water, e. g., using diffusion-weighted MRI.
• We can check how well our MRI system is calibrated by measuring the temperature conventionally (i. e., with a thermometer) and compare the MRI-determined diffusion coefficient with a reference value.
• An elegant variant of the previous approach is to use an ice-water phantom (i. e., a sample of liquid water floating in a mixture of ice and water such that the temperature is known to be 0 °C) as suggested in a publication by T. L. Chenevert et al. (2011).

The web document introduced above provides an interactive interface to calculate self-diffusion coefficients of water at different temperatures (or, alternatively, to calculate the temperature corresponding to a given diffusion coefficient). This calculation is based on the results taken from several published articles with exactly this kind of data (namely, measured diffusion coefficients of water at different temperatures).

The web page has actually existed for quite some time (since about 2002), but it was never made public. No (hyper)links to it existed and it was used only by me (and by some colleagues and our Master or PhD students). Thus, I was somewhat surprised when I recently found out that the page is indexed by google and has already been cited in several reports and theses. Consequently, I decided to slightly update its content (and to pretty up its appearance). The most relevant change is that I added a non-linear (quadratic) fit that describes the data in the Arrhenius plot much more accurately (and can be used for data over a greater temperature range) than the previously used linear fit. Note that using the (recommended) quadratic fit, calculated diffusion coefficients for intermediate temperatures around 15 to 30 °C will differ from those of the earlier (linear) version by a few tenths of a percent.

Categorized: diffusion, MRI, NMR, physics, reference values
pdf version available
URL: <https://dtrx.de/od/mmm/mmm_20180425.html>

## Double field strength gives double SNR – or not?

posted on 2018-02-22 (by Olaf Dietrich)

Some time ago at lunch, we had a discussion about the advantages of high magnetic field strengths B0 in MRI. We happily agreed that higher field strengths result in higher signal-to-noise ratios (SNR). But then several opinions surfaced about the exact quantitative relation between the SNR and B0 – ranging from linear to quadratic and including some very specific exponents in between such as 7/4. It turns out that more than one correct answer exists … and there are some surprising technical subtleties. Discussed relationships of signal-to-noise ratio (SNR) and magnetic field strength B0

As starting point of a quantitative discussion, we have to define what we consider as SNR in MRI: The SNR (sometimes given the symbol Ψ) is defined as the amplitude of the image signal (at some point or region of interest) divided by the standard deviation of the noise signal. (There are other SNR definitions used in other disciplines that involve squared amplitudes (signal power) and logarithms (resulting in decibels), but in MRI we generally use the very simple ratio of the signal amplitude and the noise standard deviation.)

To simplify things, we can divide the analysis of field strength and SNR into two parts: the discussion of the signal and of the noise. The signal part is rather straight forward: If the field strength B0 increases, then

• the Larmor (precession) frequency ω = γB0 of the nuclei increases proportionally with B0 (the proportionality constant γ is the gyromagnetic ratio)
• and the nuclear magnetization MN increases; for realistic field strengths and “normal” temperatures (around 300 K), the nuclear magnetization is approximately proportional to the field strength MN ≈ χv B0, where χv is the nuclear magnetic (volume) susceptibility given by χv = ((N / V) γ22 I (I + 1))/(3kT) (with N / V: spin density, I: nuclear spin quantum number, k: Boltzmann constant, T: sample temperature).

The measured signal S is the voltage induced in the radio-frequency (rf) receiver coil by the precessing nuclear magnetization. As known from the theory of electromagnetic induction, this induced voltage is proportional to both the (angular) frequency ω = γB0 and the magnetization MN = χB0, and taking both factors together, we find S ∝ B02.

So, if we stop at this point, we may hope for four times the SNR at double field strength. But we haven’t considered the noise yet. And there the trouble begins …

There are several sources of noise in MRI and depending on the setup, different sources can dominate the noise generation. Generally, the thermal noise voltage Unoise can be expressed as Unoise = √( 4kTRΔf), where Δf is the signal bandwidth and R is a resistance associated to the rf receiver coil. For very small samples (milliliters), this resistance R is dominated by the actual coil resistance Rcoil. Rcoil is proportional to the square root of the Larmor frequency Rcoil ∝ √(ω) ∝ √(B0) because of the rf skin effect, which reduces the penetration depth and, thus, the conducting area of the coil wires proportional to 1 / √(ω). Therefore, Unoise ∝ Rcoil1 / 2 ∝ ω1 / 4 ∝ B01 / 4 and the resulting SNR is proportional to S / Unoise ∝ B07 / 4 in this case.

However, a different looking result is presented by A. Abragam in his classic monograph “The principles of nuclear magnetism” (1961). There (on p. 83) we find for the SNR Ψ ∝ √(Q)B03 / 2 with the coil quality factor Q. This is derived from the shunt resistance R = QLω of a circuit (here the receive coil) with inductance L. This apparently contradicting result can be explained if the frequency dependence of the quality factor Q ∝ √(ω) (for a Q-optimized solenoid coil) is considered, which then gives the same exponent of 7 / 4 as before.

Finally, for larger samples – such as human subjects in clinical MRI – additional noise is generated because of the inductive (or magnetic) losses associated with the electrical conductivity of the sample or tissue. Electrical power is dissipated in the sample proportional to the squared induced voltage in the sample, i. e., proportional to ω2 and proportional to the squared current I2 in the coil. This dissipation of power can therefore be expressed as an additional apparent coil resistance Rsample that is also proportional to the squared Larmor frequency Rsample ∝ ω2. Consequently, considering only this apparent coil resistance associated to the sample, we find Unoise ∝ Rsample1 / 2 ∝ ω ∝ B0, and now the resulting SNR is proportional to S / Unoise ∝ B0.

These results (and detailed derivations) can be found in two classic MRI papers by D. I. Hoult and R. E. Richards (1976) and by D. I. Hoult and P. C. Lauterbur (1979).

An obvious question now is: Can’t we simply measure the SNR dependence on the field strength to find out what’s actually going on in MRI? Well, we can try, but there are several complications. One major problem is that we cannot use the same rf coils at different field strengths. There will generally be differences of the coil design for different field strengths and these must be expected to influence the measured SNRs. Another complication is the influence of the electromagnetic wavelengths in tissue that approach the dimensions of the samples at about 3 to 7 T. Furthermore, the relaxation times (T1, T2, T2*) change with B0 and may influence SNR measurements.

Nevertheless, there are some publications reporting SNRs at different field strengths, e. g. by D. I. Hoult et al. (1986), J. T. Vaughan et al. (2001), C. Triantafyllou et al. (2005), and recently by R. Pohmann et al. (2016). They all show a clear increase of SNR with B0, but there are still some discrepancies with respect to the exact dependency. Particularly the latest paper by R. Pohmann et al. demonstrates and discusses a slightly better than linear increase of SNR at high fields. But in conclusion and as rule of thumb, assuming an approximately linear relationship of SNR and B0 appears still justified for large (clinical) MRI systems.

Categorized: MRI, NMR, physics, signal-to-noise ratio, SNR
pdf version available
URL: <https://dtrx.de/od/mmm/mmm_20180222.html>

## Is T2 necessarily shorter than T1?

posted on 2018-01-17 (by Olaf Dietrich)

If you are familiar with MRI (or NMR in general), then probably also with the relaxation time constants T1 and T2. These tissue-specific (or substance-specific) constants describe how fast the nuclear magnetization returns to its equilibrium value, M0, after excitation by a pulsed radio-frequency (rf) field. Shortly summarized, T1 describes the exponential recovery of the longitudinal magnetization ML (i. e., of the magnetization parallel to the external static magnetic field B0), and T2 describes the exponential decay of the transverse magnetization MT (that is precessing in the plane orthogonal to B0). Longitudinal (blue) and transverse (red) relaxation of nuclear magnetization after a 90° rf pulse

Typically (as shown in the first figure), T2 values of tissue are considerably lower than T1 values, i. e., the transverse magnetization decays quicker than the longitudinal relaxation needs for recovery. For most tissues in vivo, T1 varies between about 300 ms and 3 s, while T2 varies between about 10 ms and 200 ms. Longer T2 relaxation times (up to about 3 s as well) are found for liquids.

So one may ask if there are good physical reasons for T2 values being shorter than or – at most – equal to T1. As a physicist, I’d start with checking some extreme cases, e. g., assuming that T2 is much longer than T1, i. e. T2 ≫ T1. Then the longitudinal magnetization can fully recover while at the same time some transverse magnetization would be preserved. As a result, the magnitude of the total magnetization √(ML2 + MT2) would become greater than the equilibrium value M0 – which is physically impossible.

To analyze these properties of T1 and T2 in more detail, longitudinal and transverse relaxation can also be plotted together in a diagram showing the transverse magnetization on the horizontal axis and the longitudinal magnetization on the vertical axis. These diagrams show the evolution of the magnetization (for experts: in a rotating frame of reference) after a 90° rf pulse (all trajectories start at the lower right corner of the diagram). The left-hand side of the following figure shows three cases T2 = T1 / 2 (blue), T2 = T1 (green), and T2 = 2 T1 [sic!] (cyan); and all three curves show a “benign” behavior in that they lie in the shaded area below the black circle segment ML2 + MT2 = M02. This means that the magnitude of the total magnetization vector is always smaller than M0. Evolution of the magnetization after a 90° rf pulse for T2 ≤ 2 T1 (left hand side) and T2 > 2 T1 (red curve on right-hand side)

However, the right-hand side of this figure shows what’s happening if T2 becomes greater than 2 T1 – in this case, T2 = 3 T1 (red curve): Now the magnitude of the total magnetization vector increases above the physical limit of M0, i. e., the red line crosses the black border of physically benign behavior!

In fact, it can be shown (see appendix if interested) that the maximum T2 value, for which the red curve stays always below the black line, is exactly T2 = 2 T1. And as so often, almost everything that is physically possible is also realized in nature (although the case T1 < T2 < 2 T1 is really extremely rare), as described by Malcolm H. Levitt in his highly recommendable NMR text book “Spin dynamics” (2nd ed., section 11.9.2, note 13):

The case where T2 > T1 is encountered when the spin relaxation is caused by fluctuating microscopic fields that are predominantly transverse rather than longitudinal. One mechanism which gives rise to fields of this form involves the antisymmetric component of the chemical shift tensor (not to be confused with the CSA). […] Molecular systems in which this mechanims is dominant are exceedingly rare (see F. A. L. Anet, D. J. O’Leary, C. G. Wade and R. D. Johnson, Chem. Phys. Lett., 171, 401 (1990)).

So, the answer to the title question is: No, T2 can in fact be greater than T1 in very special circumstances, but it can never be greater than 2 T1.

### Appendix

The maximum T2 value, for which the red curve stays always below the black line, is exactly T2 = 2 T1. This can be seen by analyzing the inequality

MT2 + ML2 = (M0 exp(–t / T2))2 + (M0 (1 – exp(–t / T1))2 ≤ M02.

First, we divide by M02 and set T2 = αT1 as well as β = exp(–t / T1), yielding

(β1 / α)2 + (1 – β)2 = β2 / α + 1 – 2β + β2 ≤ 1

which is (after subtraction of 1 and division by β)

β2 / α – 1 – 2 + β ≤ 0  or  β2 / α – 1 ≤ 2 – β.

β is by definition (for positive t) between 0 and 1, so the right-hand side of the last inequality is a linear function descending from 2 to 1 (i. e. always  ≤ 2). Its left-hand side has very different shapes depending on α: it is increasing from 0 to 1 for 0 < α ≤ 2 (since then the exponent 2 / α – 1 ≥ 0); but it is going to infinity for β → 0 if α > 2 (since then the exponent 2 / α – 1 < 0). So, the last inequality will not hold in the latter case for sufficiently small values of β, which means that non-physical behavior occurs if α > 2 or, using the definition from above, if T2 > 2 T1.

Categorized: MRI, physics, relaxation
pdf version available
URL: <https://dtrx.de/od/mmm/mmm_20180117.html>

## Gadolinium does not increase the signal, but the speed of MRI

posted on 2017-12-22 (by Olaf Dietrich)

You may have heard that gadolinium-based MRI contrast agents can enhance or increase the signal of tissue. This is generally a good description of what’s going on. Here, however, I would like to argue why this is – strictly speaking – not true: contrast agents cannot really increase the signal available for MRI.

Some basic facts first: gadolinium-based contrast agents are very frequently used in clinical MRI to improve the image contrast as illustrated in the following example. T1-weighted MRI without (left) and with (right) contrast agent

An important fact about (conventional) MRI contrast agents is that it’s never the contrast agent itself that is visible in MR images. Instead, the contrast agent changes the behavior of the atomic nuclei in its neighborhood – in clinical MRI, these are the nuclei of hydrogen, i. e. the protons. As a consequence, these protons now appear brighter in T1-weighted MRI than protons which are not influenced by the contrast agent.

So, apparently the proton signal is increased by gadolinium? Yes, apparently … Actually, there is always a maximum signal that is available for MRI and that depends on three major factors:

• the number of available protons, which is related to the proton density ρ of the tissue: the more protons (per voxel), the higher the signal;
• the magnetic field strength B0: the higher the field strength, the higher is also the (thermal) nuclear magnetization and, hence, the measured signal;
• the receiver coil: the more efficient the receive system (the radio-frequency coil), the higher the signal.

But the presence of a contrast agent does not increase this maximum signal.

Instead, we are cheating: First, we artificially decrease the MRI signal by choosing short repetition times (TR). And only afterwards, a certain part of this suppressed signal is recovered due to the influence of the contrast agent! This is illustrated in the following diagram: Effect of contrast agent on MRI signal

Obviously, the maximum signal, Smax, with contrast agent is exactly the same as the maximum signal without contrast agent – but we can obtain this maximum signal considerably faster (i. e, at shorter TRs). That’s why gadolinium can be described to increase the speed, but not the MRI signal. In agreement with this observation, no additional gadolinium-induced signal enhancement can be found in proton-density-weighted MR images (with very long TRs). But, hypothetically, if contrast agent could be distributed homogeneously in the tissue (which in reality is not possible), then PD-weighted MRI could be accelerated by using shorter TRs without changing the contrast.

Categorized: MRI, physics, contrast
pdf version available
URL: <https://dtrx.de/od/mmm/mmm_20171222.html>

## Simultaneous multi-slice excitation done differently

posted on 2017-12-15 (by Olaf Dietrich)

Last week, Koray Ertan and colleagues published an MRM paper (doi: 10.1002/mrm.27031) (expanding on an ISMRM abstract presented earlier this year) with an interesting approach for simultaneous multi-slice excitation. So, what’s it about?

In MRI, we are frequently interested in data from a single two-dimensional slice of the imaged subject or object – or actually in data from several such slices. These slices are then displayed as conventional 2D MR images. A procedure called slice selection is used to restrict our data acquisition to each single slice. To understand slice selection, one has to know that MRI is based on the resonant excitation of spins in a static magnetic field B0. Spins have a characteristic, so-called Larmor frequency ω = γB depending on the magnetic field B (the constant of proportionality γ is the gyromagnetic ratio). By applying a radio-frequency (rf) field with exactly this Larmor frequency, spins can be excited (i. e., they can be made to generate a measurable signal).

The basic idea of slice selection is to excite only spins in a single slice by (first) superposing a linear magnetic field gradient gz e. g. in z direction, resulting in the spatial field distribution (shown in the first figure):

B(x,y,z) = B0 + gz z.

(These linear magnetic fields or gradient fields are one of the basic ingredients of MR imaging. Each MR imager comes with built-in coils to apply gradient fields in all possible spatial orientations.)

Then, by choosing an rf frequency ωslc = 2πfslc, we can select a plane in space where

ωslc = γB(x,y,z) = γB0 + γgz zslc,

and only spins in this plane centered around zslc = (ωslc / γ – B0) / gz are excited (see first figure). Slice selection of a single slice in z direction

More advanced MRI techniques can excite several spatially separated slices at once by applying rf fields with more than one frequency – the difficult part is then to separate data acquired from these slices for reconstruction. Simultaneous slice selection of two slices in z direction

The nice idea realized in the paper by Koray Ertan et al. is to excite multiple slices not by applying rf fields with a mixture of several frequencies, but instead by modifying the gradient field to a spatially non-linear magnetic field. Consequently the mapping between frequencies ω and spatial positions (z) is no longer one-to-one, but several positions can correspond to a single frequency: Simultaneous slice selection of two slices in z direction using non-linear magnetic fields

So, depending on the shape of the magnetic field variation two or more slices can be excited using a single excitation frequency. This has the advantage that we can use short and simple standard rf pulses for slice excitation. The obvious disadvantage is that it requires additional gradient hardware providing the non-linear magnetic fields, which is currently not available at existing MRI systems.

However, this may change in future, since there are currently some promising approaches for non-linear encoding fields. In particular, I’m thinking about an impressive MRM paper (doi: 10.1002/mrm.26700) by Sebastian Littin and colleagues published also this year, in which an 84-channel matrix gradient coil is presented, which is capable of providing very flexible linear or non-linear field configurations.

Categorized: MRI, physics, publications
pdf version available
URL: <https://dtrx.de/od/mmm/mmm_20171215.html>